Debabrata Pruseth and Pooja Subramanian take a sweeping look at how managers can use psychology to mitigate the challenges of today’s changed work environment. The article describes how their Prism View Framework can help us change our work culture, which is based on planning and certainty, to embrace uncertainty. This involves understanding employees’ mental well-being; their need for meaningful goals and flexibility; and the roles of digitization, personalization, and communication. The article also discusses the softer skills that managers can (and should) use to form and sustain successful teams, including self-awareness, self-regulation, motivation, empathy, and social skills.