COVID-19 is spreading at fast speed, and time is of the essence to share, coordinate, and take actions to mitigate pandemic propagation. Current centralized database solutions solve part of the problem, but require an overarching and time-consuming coordination between multiple government and health authorities, including the entire chain of decision makers to collect test data, analyze/diagnostic, register, monitor, and enforce regulations and policies to isolate and monitor COVID-19 cases. Blockchain DLT technology solves the coordination challenges of broken healthcare centralized data lake silos, creating an open, trusted, immutable, and decentralized data architecture framework to speed up a multi-party, end-to-end COVID-19 data-sharing coordination process, while preserving patients’ data privacy.